Recombinant Human IL-23 Recetor/IL-23R Protein (Fc Tag)(Active) Sizes: 10μg, 50μg Catalogue Numbers: PKSH032579-10, PKSH032579-50 Citations, Manuals and MSDS Available upon request. Abbreviation: IL-23 Recetor; IL-23R Target Symptom: Interleukin-23 receptor; IL23R; IL-23 receptor; IL-23R Research Area: Signal Transduction; epigenetics and nuclear signal; immunology; Target Species: Human Expression Host: HEK293 Cells Application: ELISA Fusion Tag: C-Fc UNIProt ID: Q5VWK5 Accession: Q5VWK5 Background: Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits; the IL12Rβ1 subunit; which is shared with several cytokines; and a subunit that is unique to IL-23. IL23; after binding to IL23R; activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells; NK cells; dendritic cells; and macrophages. In fact; polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis; multiple sclerosis; Graves' s ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor. Activity: Immobilized Human IL-23-His at 0.1μg/ml(100 μl/well) can bind Human IL-23R-Fc. The ED50 of Human IL-23R-Fc is 3. 78 ug/ml. Sequence: Gly24-Asp353 Purity: > 90 % as determined by reducing SDS-PAGE. Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. Reconstitution: Please refer to the printed manual for detailed information. Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method. Calculated MW: 65.0 kDa Observed MW: 90-120 kDa Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. Shipping: This product is provided as lyophilized powder which is shipped with ice packs. Research Use Only