Glucose 6 phosphatase 2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65759-50, BS65759-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: Q9NQR9

Host: Rabbit

Reactivity: Human, Mouse, Rat,Cow, Horse, Rabbit, Sheep,

Applications: WB

All Applications: WB=1:500-2000

Background: Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-alpha, a second form, designated G6Pase-∫, contributes to blood glucose homeostasis in a wider range of tissues. Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), a homolog of the catalytic subunit of G6Pase, may play a role in the regulation of islet metabolism and in insulin secretion induced by metabolites. The exact catalytic acivity of IGRP is not defined. Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resulting from insulin secretion defects. Structurally, IGRP has been shown to be a glycoprotein held in the endoplasmic reticulum by nine transmembrane domains, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides.

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Glucose 6 phosphatase 2 Polyclonal Antibody detects endogenous levels of Glucose 6 phosphatase 2 protein.

Bioworld Molecular Weight: 42 kD

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Anti-Glucose 6 phosphatase 2 at 1/1000 dilution

Alternative Name: G 6 Pase 2; G 6 Pase2; G6Pase 2; G6Pase2; G6PC 2; G6pc rs; G6pcrs; Glucose 6 phosphatase 2; Glucose 6 phosphatase, catalytic, 2; Glucose 6 phosphatase, catalytic, related; Glucose 6 phosphate catalytic 2; Islet specific G6CP related protein; Islet specific glucose 6 phosphatase; Islet specific glucose 6 phosphatase catalytic subunit related protein; G6PC2_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human Glucose 6 phosphatase 2/IGRP:31-130/355

Conjugate: Unconjugated

Modification: Unmodified