γ-AA peptide P6 is a potent activator of E6 associated protein (E6AP). γ-AA peptide P6 can stimulate the self-ubiquitination of E6AP and E6AP-catalyzed substrate ubiquitination in reconstituted reactions in vitro. γ-AA peptide P6 can also enhance the ubiquitination of E6AP substrates in the cell and accelerate their degradation by the proteasome.

Product information

Molecular Weight: 1323.68

Formula: C73H98N10O11S

Smiles: CC(C)C[C@H]1CN(CC(N)=O)C(=O)CCSCC2C=CC(=CC=2)C(=O)N[C@H](CN(CC(=O)N[C@H](CN(CC(=O)N[C@@H](CC2C=CC=CC=2)CN(CC(=O)N1)C(=O)CC1CC1)C(=O)CC1C=C(C=C(C=1)OC)OC)CC(C)C)C(=O)CC1=CC2=CC=CC=C2C=C1)CCCCN

InChiKey: DIYZJKYZUDXFDG-YYHFWCTESA-N

InChi: InChI=1S/C73H98N10O11S/c1-49(2)30-60-41-80(44-65(75)84)69(88)27-29-95-48-53-21-25-57(26-22-53)73(92)79-59(18-12-13-28-74)40-81(71(90)37-54-23-24-56-16-10-11-17-58(56)32-54)45-66(85)77-61(31-50(3)4)42-82(72(91)38-55-34-63(93-5)39-64(35-55)94-6)47-68(87)78-62(33-51-14-8-7-9-15-51)43-83(46-67(86)76-60)70(89)36-52-19-20-52/h7-11,14-17,21-26,32,34-35,39,49-50,52,59-62H,12-13,18-20,27-31,33,36-38,40-48,74H2,1-6H3,(H2,75,84)(H,76,86)(H,77,85)(H,78,87)(H,79,92)/t59-,60-,61-,62-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Bo Huang, et al. Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic γ-AA Peptide. J Med Chem. 2022 Feb 10;65(3):2497-2506.

Products are for research use only. Not for human use.