Collagen I Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20780-50, RA20780-100

Citations, Manuals and MSDS Available upon request.

Background: collagen type I alpha 2 chain (COL1A2) Homo sapiens This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000, ELISA 1:10000-20000

Alternative Names: Collagen alpha-2 (I) chain (Alpha-2 type I collagen)

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 1278

Protein MW (KDa): 115

SWISS: P08123

Source: Rabbit

Research Use Only