Space Puppies is a deck-building game for 2-5 players. Each player begins with 5 cards and can take 2 actions per turn: play a dog in front of you, play an action card, save a planet, or discard a card.

Once a player completes a set of dog cards, they choose one of the planets on the dog cards to save, thus earning points. Play continues in turn order, with each player taking 2 actions per turn.

The endgame trigger is chosen at the beginning of the game; the game can end when someone scores 40 points or when someone has saved 3 planets.